Cat No.
CEI-0473
Description
A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC50 = 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC50 of
Product_Overview
A potent EZH2 inhibitor
Targets
EZH2
Chemical Name
1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridine-4-yl)-1H-indazole-4-carboxamide
M.Wt
652.7
Purity
>95% by HPLC
Appearance
Liquid
Formulation
DMSO (2 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from light and moisture
Usage
For Research Use Only! Not For Use in Humans.
