Cat No.
CEI-0481
Description
Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.
CAS No.
191282-48-1
Product_Overview
A FAS inhibitor
Targets
FASN
Chemical Name
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
M.Wt
515.86
Purity
>98% by TLC
Appearance
White solid
Solubility
H?O (100 mM)
Storage
-20 centigrade
Shipping Conditions
RT
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
