Cat No.
CEI-0480
Description
An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC50 = 180 μM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 μM).μM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.
Alias
NSC-622141; UFC 1C
Synonyms
NSC-622141; UFC 1C
CAS No.
52665-74-4
Product_Overview
A potent ras farnesyltransferase (FTase) inhibitor
Targets
FNTB
M.Wt
302.78
Purity
>90% by NMR
Appearance
Off-white solid
Solubility
DMSO (100 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
