Cat No.
CEI-0226
Description
Tipifarnib (Zarnestra) can inhibit farnesyltransferase with IC50 of 0.6 nM.
Alias
R115777
Synonyms
R115777
CAS No.
192185-72-1
Targets
farnesyltransferase
Chemical Name
(R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
M.Wt
489.4
Purity
>99%
Solubility
DMSO 14 mg/mL Water
Storage
2 years at -20centigrade Powder
In vitro
As an Tipifarnib (formerly known as R-1 15777), an inhibitor of RAS farnesylation, for the potential treatment of neoplasia. Tipifarnib can inhibit farnesyltransferase with IC50 of 0.6 nM. Tipifarnib is an oral, very potent, and highly selective FTI (farnesyltransferase inhibitors) with a relatively low toxicity profile. FTIs function by competitively inhibiting the addition of a farnesyl moiety to several important signaling molecules 3 and thus target multiple pathways, including the RAS pathway implicated in the pathogenesis of solid and hematologic malignancies.
