Cat No.
CEI-0490
Description
A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.
Alias
Koningic acid; Avocettin; FO-4443; BRN 5091359
Synonyms
Koningic acid; Avocettin; FO-4443; BRN 5091359
CAS No.
74310-84-2
Product_Overview
A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor
Targets
GAPDH
M.Wt
327.42
Purity
>96% by HPLC
Appearance
White solid
Solubility
H?O
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
