Cat No.
CEI-0375
Description
4-Methylumbelliferone
Alias
4-MU
Synonyms
4-MU
CAS No.
90-33-5
Targets
HA synthesis
Chemical Name
1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
M.Wt
176.17
Purity
>99%
Solubility
DMSO 35 mg/mL, Water
Storage
2 years at -20 centigrade
In vitro
4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling.
