Cat No.
CEI-0225
Description
VX-222
Alias
VCH222
Synonyms
VCH222
CAS No.
1026785-55-6
Targets
HCV NS5B 1alpha, HCV NS5B 1beta
M.Wt
445.61
Purity
>99%
Solubility
No
Storage
2 years at -20 centigrade
In vitro
As a nonnucleoside inhibitor, VX-222 (VCH-222) can potently and selectively inhibit HCV polymerase with IC50 of 0.94-1.2 uM. VX-222 binds to the HCV polymerase with dissociation constants of 17 nM. VX-222 can inhibit HCV replication via NS5B (polymerase of hepatitis C virus).VX-222 interfered with the interaction between NS5B and RNA. VX-222 inhibited the 1b/Con1 HCV subgenomic replicon, with EC50 of 5 nM. The inhibitory activity of VX-222 was only modestly affected by the M423T substitution but more significantly affected by an I482L substitution.
