Cat No.
CEI-0981
Description
CI-994 is a histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation. CI-994 inhibited HDAC-1 and HDAC-2 but not GCN5. CI-994 is also a novel antitumor agent, exhibiting activity against pancreatic, colon and mammary tumors. CI-994 inhibited the growth of two non-small cell lung cancer cell lines, A-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma), with an IC50 of 80 μM.
Abbr
CI-994
Synonyms
Acetyldinaline, G? 5549, PD 123654, Tacedinaline
CAS No.
112522-64-2
IC50
80 μM
Targets
HDAC-1, HDAC-2
M.Wt
269.3 Da
Purity
>99%
Appearance
White to off-white powder
Solubility
Soluble in DMSO at 66 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-100 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Stability
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
