Cat No.
CEI-0507
Description
An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg.
Alias
Pracinostat
Synonyms
Pracinostat
CAS No.
929016-96-6
Product_Overview
A pan-HDAC inhibitor
Targets
HDAC
Chemical Name
3-?[2-?butyl-?1-?[2-?(diethylamino)ethyl]-?1H-?benzimidazol-?5-?yl]-?N-?hydroxy-?2E-?propenamide
M.Wt
376.86
Purity
>98% by HPLC
Appearance
Pale yellow solid
Solubility
DMSO (~ 50 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from light and moisture
Usage
For Research Use Only! Not For Use in Humans.
