Cat No.
CEI-0504
Description
Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 μM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.
CAS No.
743420-02-2
Product_Overview
A potent histone deacetylase inhibitor
Targets
HDAC
Chemical Name
N-?(2-?amino-?5-?fluorophenyl)-?4-?[[[1-?oxo-?3-?(3-?pyridinyl)-?2-?propen-?1-?yl]amino]methyl]-?benzamide
M.Wt
382.45
Purity
>95% by HPLC
Appearance
White solid
Solubility
DMSO (200 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
