Cat No.
CEI-0982
Description
CUDC-101 is a potent inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively. It inhibted EGFR and Her2 phosphorylation, reduced cell proliferation and induced apoptosis in HCC827 non-small cell lung cancer (NSCLC) xenografts. CUDC-101 inhibited EGFR and induced upregulation of acetylated histone H3 in a dose-dependent fashion.
Abbr
CUDC-101
CAS No.
1012054-59-9
IC50
HDAC、EGFR、HER2 ： 4.4, 2.4, and 15.7 nM respectively
Targets
HDAC, EGFR, HER2
M.Wt
434.5 Da
Purity
>99%
Appearance
White solid.
Solubility
Soluble in DMSO at 28 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Stability
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
