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Cat No.
CEI-0583
Description
A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 μM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.
Product_Overview
A necrosis inhibitor
Targets
Necroptosis
Chemical Name
[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
M.Wt
654.7
Purity
>99% by HPLC
Appearance
Liquid
Formulation
DMSO (2 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from light and moisture
Usage
For Research Use Only! Not For Use in Humans.
