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Cat No.
CEI-0592
Description
A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively). L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC?? of 0.54 μM.
Alias
NG-Nitro-L-arginine methyl ester hydrochloride
Synonyms
NG-Nitro-L-arginine methyl ester hydrochloride
CAS No.
51298-62-5
Product_Overview
A pro-drug of the NOS inhibitor L- NG-Nitro-L-arginine
Targets
NOS1, NOS3, Nos2
M.Wt
278.35
Purity
>99% by TLC
Appearance
White to off-white solid
Solubility
DMSO (~200 mg/ml) or Ethanol (~40 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
