Cat No.
CEI-0231
Description
GSK256066
CAS No.
801312-28-7
Targets
PDE4B
M.Wt
518.58
Purity
>99%
Solubility
No
Storage
2 years at -20 centigrade
In vitro
GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFalpha production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM.