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Cat No.
CEI-0237
Description
Vardenafil
Alias
Levitra, Vivanza
Synonyms
Levitra, Vivanza
CAS No.
224785-90-4
Targets
phosphodiesterase type 5
Chemical Name
2-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4]triazin-4(3H)-one hydrochloride trihydrate
M.Wt
579.11
Purity
>99%
Solubility
DMSO 116 mg/mL, Water 116 mg/mL, Ethanol 20 mg/mL
Storage
2 years at -20centigrade Powder
In vitro
Vardenafil Hydrochloride Trihydrate (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. Vardenafils indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). Structurally, the difference between the vardenafil molecule and sildenafil citrate is a nitrogen atoms position and the change of sildenafils piperazine ring methyl group to an ethyl group. Chronic vardenafil treatment improves erectile function via structural maintenance of penile corpora cavernosa in rats with acute arteriogenic erectile dysfunction.
