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Cat No.
CEI-0058
Description
Crenolanib(CP-868596) can inhibit PDGFR-alpha with IC50 of 10 nM.
CAS No.
670220-88-9
Targets
PDGFR-alpha
Chemical Name
1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
M.Wt
443.54
Purity
>99%
Solubility
DMSO 89 mg/mL Water
Storage
2 years at -20centigrade Powder
In vitro
The CP-868,596 is a potent, oral, selective inhibitor of PDGFR-beta tyrosine kinase, with an IC 50 of 0.4 ng/ml while PDGFR-beta is commonly overexpressed in the stroma and pericytes of several solid organ tumour types. CP-868,596 is greater than 100-fold more selective for PDGFR than for other kinases, such as c-KIT, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
