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Cat No.
DIA-122
Description
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Adenosylhomocysteinase is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine. This enzyme catalyses the following chemical reaction: S-adenosyl-L-homocysteine + H2O? L-homocysteine + adenosine. The enzyme contains one tightly bound NAD+ per subunit.
Abbr
AHCY (Human)
Alias
SAHase; AHCY
Species
Human
Form
Purified and lyophilized powder or Purified, solution in 50% glycerol
Enzyme Commission Number
EC 3.3.1.1
CAS No.
9025-54-1
Molecular Mass
47 kDa
Gene Name
AHCY adenosylhomocysteinase [ Homo sapiens (human) ]
Synonyms
Adenosylhomocysteinase; S-adenosylhomocysteine synthase; S-adenosylhomocysteine hydrolase; adenosylhomocysteine hydrolase ambiguous; S-adenosylhomocysteinase; SAHase; AdoHcyase; EC 3.3.1.1; 9025-54-1; AHCY
GeneID
191
mRNA Refseq
NM_000687
Protein Refseq
NP_000678
Chromosome Location
20q11.22
Pathway
Biological oxidations, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem.
Function
adenosylhomocysteinase activity
