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Cat No.
NATE-0108
Description
Catalase activates the decomposition of hydrogen peroxide, a reactive oxygen species, into water and oxygen. It functions as a natural antioxidant, protecting cells against oxidative damage to proteins, lipids and nucleic acids. Catalase has also been used to study the role reactive oxygen species play in gene expression and apoptosis.
Abbr
CAT, Native (Human)
Alias
Catalase; CAT
Source
Human erythrocytes
Species
Human
Form
buffered aqueous solution. Solution in 50 mM Tris, pH 8.0
Enzyme Commission Number
EC 1.11.1.6
Bio-activity
> 30,000 units/mg protein
CAS No.
9001-05-2
Molecular Mass
tetramer mol wt ~250 kDa
Purification
> 90% (SDS-PAGE)
Unit Definition
One unit will decompose 1.0 μmole of H2O2 per min at pH 7.0 at 25°C, while the H2O2 conc. falls from 10.3 to 9.2 mM, measured by the rate of decrease of A240.
Gene Name
CAT catalase [Homo sapiens]
Synonyms
EC 1.11.1.6; Catalase; catalase; equilase; caperase; optidase; catalase-peroxidase; CAT; H2O2:H2O2 oxidoreductase; 9001-05-2
GeneID
847
mRNA Refseq
NM_001752
Protein Refseq
NP_001743
MIM
115500
UniProt ID
P04040
Chromosome Location
11p13
Pathway
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Folate Metabolism, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem
Function
NADP binding; aminoacylase activity; catalase activity; catalase activity; heme binding; metal ion binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity
