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Cat No.
NATE-0149
Description
COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid.
Abbr
COX-1, Native (Sheep)
Alias
COX-1
Species
Sheep
Form
aqueous solution. Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN 20 and 300 μM diethyldithiocarbamate.
Enzyme Commission Number
EC 1.14.99.1
Bio-activity
> 40,000 units/mg protein
Molecular Mass
dimer subunit mol wt 70 kDa
Purification
> 95% (SDS-PAGE),
Unit Definition
One unit consumes one nanomole of oxygen per minute at 37°C in 0.1 M Tris-HCl buffer, pH 8, containing 100 μM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 μM hematin.
Gene Name
COX1 cytochrome c oxidase subunit I [Ovis aries]
Synonyms
COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase
GeneID
808251
Protein Refseq
NP_008408
UniProt ID
O78749
Pathway
Alzheimer's disease, organism-specific biosystem; Cytochrome c oxidase, organism-specific biosystem; Huntington's disease, conserved biosystem
