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Cat No.
NATE-0323
Description
Glutathione peroxidase is an enzyme which reduced lipid hydroperoxides into their corresponding alcohols. It also reduces free hydrogen peroxide in to water. In vivo it is responsible for protecting hemoglobin from oxidative breakdown.
Abbr
GSH-Px, Native (Human)
Alias
GSH-Px
Source
Human erythr ocytes
Species
Human
Form
Lyophilized powder containing 25% sucrose, 3% dithiothreitol, and sodium phosphate buffer salts
Enzyme Commission Number
EC 1.11.1.9
Bio-activity
> 30 units/mg protein
CAS No.
9013-66-5
pH Stability
8.8
Unit Definition
One unit will catalyze the oxidation by H2O2 of 1.0 μmole of reduced glutathione to oxidized glutathione per min at pH 7.0 at 25°C.
Optimum pH
8.8
Gene Name
GPX1 glutathione peroxidase 1 [Homo sapiens]
Synonyms
EC 1.11.1.9; GSH peroxidase; selenium-glutathione peroxidase; reduced glutathione peroxidase; 9013-66-5; GSH-Px, Glutathione:hydrogen-peroxide oxido-reductase; Glutathione Peroxidase
GeneID
2876
mRNA Refseq
NM_000581
Protein Refseq
NP_000572
MIM
138320
UniProt ID
P07203
Chromosome Location
3p21.3
Pathway
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem
Function
SH3 domain binding; endopeptidase inhibitor activity; glutathione peroxidase activity; glutathione peroxidase activity; oxidoreductase activity
