点击图片查看原图
Cat No.
NATE-0419
Description
Leukotriene A4 Hydrolase human (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into Leukotriene B4, and also demonstrates aminopeptidase activity. Leukotriene B4 is a lipid chemoattractant that plays critical roles in inflammaton, immune responses, host defenses against infections, and lipid homeostasis. Inhibition of LTA4H in a mouse model decreases LTB4 in the airways and attenuates airway inflammation and airway hyperreactivity through modulation of T cell and dendritic cell function.
Abbr
LTA4H, Recombinant (Human)
Alias
LTA4H; LTA4
Source
E. coli
Species
Human
Form
Supplied as a solution in 100mM Tris, pH 8.0, containing 20% glycerol and 100mM potassium chloride.
Enzyme Commission Number
EC 3.3.2.6
CAS No.
90119-07-6
Molecular Mass
mol wt ~69 kDa
Applications
Leukotriene A4 Hydrolase human (LTA4H) is a drug target for anti-inflammation, and for cancer prevention and therapy. It is also suitable for screening inhibitors of Leukotriene B4 synthesis. LTA4H is used to study allergic asthma and airway hyperresponsiveness
Gene Name
LTA4H leukotriene A4 hydrolase [Homo sapiens]
Synonyms
leukotriene-A4 hydrolase; LTA-4 hydrolase; LTA4; LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase; EC 3.3.2.6; 90119-07-6
GeneID
4048
mRNA Refseq
NM_000895
Protein Refseq
NP_000886
MIM
151570
UniProt ID
P09960
Chromosome Location
12q22
Pathway
Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Leukotriene synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem
Function
aminopeptidase activity; binding; epoxide hydrolase activity; epoxide hydrolase activity; leukotriene-A4 hydrolase activity; leukotriene-A4 hydrolase activity; metal ion binding; metallopeptidase activity; peptidase activity; zinc ion binding
