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Cat No.
CEI-0278
Description
Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.
CAS No.
901-47-3
Targets
APC
Chemical Name
(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate
M.Wt
342.41
Purity
>99%
Solubility
DSMO 69 mg/mL Water 69 mg/mL Ethanol 3 mg/mL
Storage
2 years at -20 centigrade
In vitro
TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM. TAME at concentration of 1-200 uM arrests interphase extract treated with recombinant cyclin B1/Cdc2 complex in mitosis, with stable cyclin B1 and phosphorylated Cdc27. TAME accelerates the ATP hydrolysis process about 12-fold. TAME interacts with beta and gamma phosphate and the adenine ring of ATP by the guanidinium group and the aromatic ring.
