生物发酵产品目前能达到的水平参考大全

ITEMS TECH DATA REMARKS IMMUNOSUPPRESSIVE AGENT 他克莫司 Tacrolimus Final Titre:600-700mg/L Fermentation time:168hrs Recovery:40% FK506 霉酚酸 Mycophenoic acid Final Titre:15g/L Fermentation time:264hrs Recovery:70% Intermediate for MMF 环孢菌素 A Cyclosporin A Final Titre: 10g/L Fermentation Time:168hrs Recovery:70% 雷帕霉素(西罗莫司) Rapamycin(Sirolimus) Final Titre: 600-800g/L Fermentation Time:216hrs Recovery:60% Or intermediate for Zotarolimus, Everolimus and 子囊霉素 Ascomycin Final Titre: 500g/L Fermentation Time:216hrs Recovery:60% FK520 Or Intermediate for Pimecrolimus ANTIBIOTICS 阿莫西林 AMOXICILLIN By enzyme process 万古霉素 Vancomycin Final Titre:9-10g/L Fermentation Time: 150hrs Recovery:>70% 替考拉宁 Teicoplanin Final Titre:4-5g/L Fermentation Time: 150hrs Recovery:>70% 达托霉素 Daptomycin Final Titre2.0g/L Fermentation Time: 200hrs Recovery:>40% Or cubicin 莫匹罗星 Mupirocin Final Titre:4-5g/L Fermentation Time:60-70hrs Recovery:>75% Pneumocandin B0 Final Titre:1.7g/L Fermentation Time: 11-12days Recovery:>60% Caspofungin 雷莫拉宁 Ramoplanin Final Titre:3g/L Fermentation Time: 200hrs Recovery:>60% 普那霉素（原始霉素） Pristinamycin Final Titre:8/L Fermentation Time: 150hrs Recovery:>70% 克拉维酸（棒酸） Clavulanic acid Final Titre:6g/L Fermentation Time:105hrs Recovery:55% 头孢菌素 C Cephalosporin C Final Titre:40g/L Fermentation Time:168hrs Recovery:80% 各种头孢类中间体 青霉素G Penicillin G Final Titre:120000g/L Fermentation Time:220hrs Recovery:80% 红霉素 Erythromycin Final Titre:9-10g/L Fermentation Time:156hrs Recovery:60% 依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体 去甲金霉素 Demethylchlortetracycline (DMCT) Final Titre:16g/L Fermentation Time:200hrs Recovery:75% Intermediate for Minocycline, Tigecylcine 林可霉素（洁霉素） Lincomycin Final Titre:9-10g/L Fermentation Time:200hrs Recovery:80-90% 克林霉素中间体 Clindamycin 杆菌肽 Bacitracin Final Titre:1200U/ml Fermentation Time:50-60hrs Recovery:95% Zinc Bacitracin for Animal feed additive 那西肽 Nosiheptide Final Titre:1700-2000U/ml Fermentation Time:50hrs Recovery:95% Animal feed additive 两性霉素B AmphotericinB Final Titre:10000U/ml Fermentation Time:130-140hrs Recovery:75% 阿维拉霉素（卑霉素） Avilamycin Final Titre:7-8g/L Fermentation Time:268hrs Recovery:95% Animal feed additive 恩拉霉素 Enramycin Final Titre:8-10g/L Fermentation Time:260hrs Recovery:95% Animal feed additive 卡那霉素 Kanamycin Final Titre:25g/L Fermentation Time:240hrs Recovery:85% 卷曲霉素 Capreomycin Final Titre:11000U/ml Fermentation Time:150-160hrs Recovery:75% 庆大霉素C Gentamicin C Final Titre:5-6g/L Fermentation Time:14days Recovery:75% 庆大霉素B Gentamycin B Final Titre:1000Mmg/L Fermentation Time:120-130hrs Recovery:75% 异帕米星 （Isepamicin） 多粘菌素B Polymyxin B Final titre 2.5 g/l Fermentation time 72 hrs Recovery yield 70% 粘杆菌素 E Polymyxin E Final titre 600000U/ml Fermentation time 96 hrs Recovery yield 75% 泰乐菌素 Tylosin Final titre 15000 U/l Fermentation time 180 hrs Recovery yield 70% 巴龙霉素 Paromomycin Final titre 8g/l Fermentation time170 hrs Recovery yield 70% 制霉菌素 Nystatin Final titre 300,000IU/ml Fermentation time 280 hrs Recovery yield 85% 盐霉素 Salinomycin Final titre 80g/l Fermentation time 268 hrs Recovery yield 90% 金霉素 Chlortetracycline Final titre 50g/l Fermentation time 200 hrs Recovery yield 90% 四环素 Tetracycline Final titre 40g/l Fermentation time 200 hrs Recovery yield 90% 土霉素 Oxytetracycline Final titre 40g/l Fermentation time 200 hrs Recovery yield 90% 链霉素 Streptomycin Final titre 28,000U/ml Fermentation time 200 hrs Recovery yield 80% 利福霉素 Rifamycin Final titre 30g/l Fermentation time 220 hrs Recovery yield 75% 黄霉素 Flavomycin Final titre 8g/l Fermentation time 168 hrs Recovery yield 90% 截短侧耳素 Pleuromutilin Final titre 14000U/ml Fermentation time 300 hrs Recovery yield 80% 泰妙菌素 Tiamulin 大观霉素 Spectinomycin Final titre 7000-10000U/ml Fermentation time 130-150 hrs Recovery yield 70% 莫能菌素 Monensin 38000u/ml Final titre 6500-8000U/ml Fermentation time 140-170 hrs Recovery yield 70-80% 妥布霉素 Tobramycin Final titre 6500-8000U/ml Fermentation time 140-170 hrs Recovery yield 70-80% 安普霉素 Apramycin Final titre 6500-8000U/ml Fermentation time 140-170 hrs Recovery yield 70-80% 尼可霉素 Nikkomycin Final titre 7-8 g/l Fermentation time 70 hrs Recovery yield 80% 麦角酸 Lysergic acid Final titre 7-8 g/l Fermentation time 360 hrs Recovery yield 70% For cabergoline and nicergoline 夫西地酸 Fusidic Acid Final titre 4-5 g/l Fermentation time 200 hrs Recovery yield 40% 麦迪霉素 Medimycin Final titre 18g/l Fermentation time 200 hrs Recovery yield 75% 莫能菌素 Monensin Final Titre:40000U/ml Fermentation Time: 300hrs Recovery:95% 马杜霉素 Maduramicin Final Titre:612000U/ml Fermentation Time: 200hrs Recovery:95% 利福霉素 RIFAMYCIN Final Titre:25g/L Fermentation Time:240hrs Recovery:80% 磷霉素 Fosfomycin 氯霉素 Chloramphenicol 灰黄霉素 Griseofulvin 螺旋霉素 Spiramycin//Rovamycin Final Titre:6000U/ml Fermentation Time: 160hrs Recovery:75% 小诺霉素 Micronomicin 维吉尼亚霉素 Virginmycin R&D 亮菌甲素（假蜜环菌素）Armillarisin a. 美贝霉素 Milbemycin Seeking 莫西菌素 Moxidectin 道拉菌素 Doramectin 土拉霉素 Tulathromvcin Seeking 米卡芬净 micafungin R&D 阿尼芬净 anidulafungin R&D Bio-PESTICIDE 阿维菌素 Abamectin Final Titre:4.5g/l Flask:4.8-5.0g/L Time:240hrs Recovery:80% Including its derivatives 多杀菌素 Spinosad Final Titre:12g/L Fermentation Time:200-240hrs Recovery:80% Bio-pesticide 井冈霉素 Validamycin Final Titre: 3-4g/L Fermentation Time:60-70hrs Recovery:80% 春雷霉素 Kasugamycin Final Titre: 8000-1000U/ml Fermentation Time:192hrs Recovery80% 多抗霉素 Polyoxin Final Titre: 5000U/ml Fermentation Time:192hrs Recovery：80% 脱落酸 Abscisic Acid (ABA) Final Titre:1.6g/L Fermentation Time:70-72hrs Recovery:60-65% Plant hormone Biopesticide 赤霉素 Gibberellin (GA3) Final Titre:2.5-2.8g/L Fermentation Time:150-160hrs Recovery:80% 中生霉素 zhongshengmycin Final Titre:10g/L Fermentation Time:1200hrs Recovery:80% 枯草芽孢杆菌 Bacillus subtilis Final Titre6000U/ml Fermentation Time:150-160hrs Recovery:80% 苏云金杆菌 Bacillus thuringiensis Final Titre:5500g/ml Fermentation Time:150-160hrs Recovery:80% 浏阳霉素 Liuyangmycin 宁南霉素 Ningnanmycin 链霉素 streptomycin For agriculture ANTI-DIABETES 米格列醇 Miglitol Final Titre:2g/L Fermentation Time:70-72hrs Recovery:60-65% Synthesis:90% 阿卡波糖 Acarbose Final Titre:5-6g/L Fermentation T, ime:130-150hrs Recovery:30-40% 伏格列波糖 Veglibose Chemical synthesis ANTI-TUMOR 柔红霉素 Daunomycin Final Titre:1.5g/L Fermentation Time:168hrs Recovery:>67% For epirubicin, Idarubicin, doxorubicin 洋红霉素 Carminomycin Final titre 0.15 g/l Fermentation time 168 hrs Recovery yield 65% 偏端霉素 Distamycin Final titre 2g/l Fermentation time 120 hrs Recovery yield 52% 博莱霉素 Bleomycin Final titre 4g/l Fermentation time 168 hrs Recovery yield 70% 紫杉醇 Paclitaxel Final titre 200mg/l Fermentation time 120 hrs Recovery yield 50% 丝裂霉素C Mitomycin C Final titre 1000mg/l Fermentation time 200 hrs Recovery yield 50% 阿霉素 Doxorubicin Chemical synthesis Or fermentation 棕霉素 Bruneomycin Final titre 150mg/l Fermentation time 144 hrs Recovery yield 60% 放线菌素D Dactinomycin D Chemical synthesis 表阿霉素 Epirubicin Chemical synthesis 伊达比星 Idarubicin Chemical synthesis 吡柔比星 Pirarubicin Chemical synthesis ANTI-CARDIVASCULAR 洛伐他汀 Lovastatin Final Titre:16g/L Fermentation Time:168hrs Recovery:70% 美伐他汀 Compactin Final Titre:10g/L Fermentation Time:200-220hrs 普伐他汀 Pravastatin Final Titre: 8.0g/l Conversion rate:70% Cycle time: 120-144 阿托伐他汀 Atorvastatin Chemical synthesis 瑞舒伐他汀 Rosuvastatin Chemical synthesis 辛伐他汀 Simvastatin Chemical synthesis 氟伐他汀 Fluvastatin Chemical synthesis ORGANNIC ACID Biobased chemicals 衣康酸 Itaconic Acid Acid:>6% Cycle time:40-50hrs Conversion:>50% Fermentation data:1.4g/L/hr The product gets to Pfizer 柠檬酸 Citric acid 莽草酸 Shikimic Acid Titre: 25g/L L-乳酸 L-Lactic acid Acid:16-18% Conversion rate; 90% 丙酮酸 Pyruvic acid Titre:55-65g/L Conversion rate:55-60% Fermentation time:60hr Recovery:70% 长链二元酸 Long-chain dicarbxylic acid DCA13-18: 180g/L, Fermentation time:5-6days Bio-based products 1，3-丙二醇 1,3-propandiol(PDO) Titre: 85g/L Conversion rate:60% Productivity:1.2-1.4g/LH Chemical 2，3-丁二醇 2,3-butandiol 50-65g/L By product from PDO 丁醇 Butanol 20g/L 甘油 Glycerol Titre:160g/l Time:78hrs Productivity:2g/LH Mass conversion rate: 48.6% Chemical 丙烯酰胺 Acrylamide Enzyme activity: 1 0g/ml Acrylonitrile consumption: 0.75t/t Conversion rate: 99.9% Chemical 烟酰胺 Nicotinamide Enzyme activity: 8g/ml Nicotinonitrile consumption: 0.85t/t Conversion rate: 99.999% Assay: 100% Chemical 羟基乙酸 Hydroxyacetic acid Enzyme activity: 0.1g/ml Glycolonitrile consumption: 0.78t/t Conversion rate: 99.9% Assay: 99.5% ( pharma grade) Chemical 黄原胶 Xanthan Final Titre:5-6g/L Fermentation Time:36hrs Recovery:80% 琥珀酸（丁二酸） Succinic acid 苹果酸 Malic acid 牛磺酸 Taurine 乙酸（醋酸） Acetic acid 聚羟基脂肪酸 Polyhydroxyalkanoates (PHAs) degradable plastics 聚乳酸 Polylactic acid, PLA VITAMIN AND CAROTENOID 维生素B2 Vitamin B2 Final titre 30g/l Fermentation time 72 hrs Recovery yield 80% 维生素B12 Vitamin B12 Final titre 250mg/l TIME:180hrs 维生素C Vitamin C Final titre 11-12g/l Fermentation time 60 hrs Conversion rate; 90% 番茄红素 Lycopene Final Titre:>1.0g/L 胡萝卜素 Beta Carotene Final Titre:2.5-3.0g/L Fermentation Time:72hrs Recovery:75-80% 虾青素Astaxanthin Final Titre:2g/L 维生素D2 Vitamin D2 Light reaction 维生素D3 Vitamin D3 Light reaction 维生素A Vitamin A chemical synthesis 维生素H Vitamin H By fermentation Or chemical synthesis Biotin HORMONE Biotransformation Hormone 雄烯二酮 Anostenedione(AD) Final titre 15 g/l Fermentation time 200 hrs Recovery yield 75% Intermediate 雄二烯二酮 androsta-1,4-diene-3,17-dione (ADD) Final titre 10 g/l Fermentation time 200 hrs Recovery yield 72% Intermediate 泼尼松龙 Prednisolone Finaltitre>20g/L(Maximum 70g/L) time：5-8 hrs conversion: 97～100％ 睾丸素 Testosterone Final Titre 5g/L 去氢甲睾酮 Methandrostenolone Final Titre 10g/L Pregna 1,4,9,17 acetate Final Titre 5g/L Pregna 1,2,9,21 Final Titre 5g/L 螺内酯 SPIRONOLACTONE 依普利酮 Eplerenone ANTISPETIC 异抗血酸 D-isoascorbate Productivity:18-20g/L 那他霉素 Natamycin Final Titre:8-10g/L Fermentation Time:140-150hrs antiseptic 乳酸链球菌素 Nisin Natural antiseptic HEALTHCARE 谷胱甘肽 Glutathione(GSH) Titre: 5g/L Biomass:140g/L Fermentation time 72 hrs Recovery yield 45% 辅酶Q10 Coenzyme Q10 Final titre2.5-3.0 g/l Fermentation time 96 hrs Recovery yield 60% 透明质酸 Hyaluronic acid (HA) Final Titre:6-7g/L Fermentation Time:20hrs Recovery:90% Best performance is 10g/L 花生四烯酸 Arachidonic acid (AA) Final titre 9+1.5 g/l Fermentation time 192hrs Recovery yield: 65% Food additives Healthcare S-腺苷甲硫氨酸 S-adenosylmethionine (SAMe) 二十二碳六烯酸 Docosahexaenic Acid(DHA) Others 普鲁兰 Pullulan Titre:60-70g/L Conversion:60-70% 灵芝多糖 Polysaccharide Final Titre: 1.5g/l Cordyceps.sinensis 赤藓糖醇 Erythritol excipient Instant Active Yeast Food processing Yeast extract Food savor 麦角固醇Ergosterol For Vitamin D Alpha-cyclodextrin excipient Beta- cyclodextrin excipient 肌苷 Inosine Productivity ：100g/L time： 90小时 conversion 35% recovery： 90% 鸟苷 Guanosine Titre :50-60g/L. time:72小时 conversion: 25% recovery: 90% WEIGHT LOSING 尼波司他汀 Lipstatin Final Titre:8-10g/L Fermentation Time:168hrs Recovery:75% Conversion:77.8% Orlistat（奥利司他） Weight losing Enzymes 酶制剂 Phytase 20000U/ml Xylase Inquiry Celluase Inquiry Amylase Inquiry Protease Inquiry Acylase, Inquiry Many other,Etc Inquiry Penicillin G amidase Amino acids Folder & food additives Medicine, Healthcare 色氨酸 L-Tryptophan Final titer 25-30 g/l 苯丙氨酸 L-Phenylalanine Final titer 40 +/- 2 g/l 苏氨酸 L-Threonine Final titer 120 g/l 精氨酸 L-Arginine Final titre > 60 g/l 缬氨酸 L-Valine Final titre 52 +/- 2 g/l 赖氨酸 L-Lysine Final titre 160 +/- 10 g/l 亮氨酸 L-Leucine， Final Titre:40g/L Fermentation Time: 65hrs Recovery:70% Conversion:20% 异亮氨酸 L-isoleucine Final Titre:30g/L Fermentation Time: 25hrs Recovery:80% 谷氨酰胺 L-Glutamine Final Titre:80g/L Fermentation Time: 65hrs Recovery:75% 谷氨酸 Glutmate productivity：180-200g/L. time：36hrs conversion rate：70% recovery ：95%